Exoria: Turning Size-Based Electrophoresis into a Preparative Workflow
Size-based electrophoresis resolves biotherapeutic variants and impurities at high resolution, but conventional analytical formats stop at detection: they provide no practical way to recover sufficient, traceable material from individual peaks for downstream structural and functional characterization. Exoria closes this isolation gap by turning size-based electrophoresis from a terminal analytical method into a preparative workflow.
What's inside
- Native fluorescence imaging cleanly resolves light chain (LC) and heavy chain (HC) subunits, and Exoria’s fractionation module selectively isolates each species with high purity and strong mass balance.
- High-resolution SeparationExoria’s native fluorescence microchip separation cleanly resolves LC and HC enabling direct visual confirmation of size-based variants.
- Selective Fraction RecoveryOrthogonal electric-field fractionation reliably isolates individual subunits, producing wells containing isolated HC or LC subunits with strong mass balance and reproducible recovery across runs.
- High-purity FractionsCapillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis of collected wells confirms high-purity isolation and accurate mixed-fraction composition.
- Authors
- Erik Gentalen, Scott Mack, Dar Bahatt, Tim Blanc, Nathan Clark, Morten Jensen, Kris Scaboo
